I use Ghostscript for all my PDF creation with great results...better than Distiller I think, especially when creating shaded image PDF's. This topic has been discussed at length in this forum. I suggest you read existing posts on this subject to answer your question in detail.
You can plot to distiller directly if you have an A or B size drawing. Just select it as the printer in the pop up window.
If your original is larger you have to plot to a post script file, rename the file extention to .ps and then use Distiller outside of Pro/E. This will make an A or B size pdf file. You have to select the size at the time of printing.
This is the manual method of doing it. To have it automated follow the links given by proed listed above.